Yosuke Hanamura and Chie Satonaka should be together in my opinion and are made for each other. They have more chemistry that Yu (the main character) with Yosuke or Chie, and that says something.

This can be seen in many occasion during the actual games (Persona 4, Persona 4 Golden, Persona 4 Arena) or the anime/manga adaptation of the games.

I'll try to give some examples in both Yosuke and Chie's perspective:

in Yosuke social link event rank 2, Yosuke recall Chie call the Souzai Daigaku's croquettes "tender and juicy". This indicates that they at least have eat together once there. Second example is the fact that Yosuke seems to often called Chie at night just to tell dirty jokes. The third one is from P4 Arena game and manga, in those event, Yosuke seems to have a lot of fun messing and spending time with Chie, and he seems to really understand how she feels. and many more.

For Chie, the first sign is when Yu and Yosuke go into the TV with a rope in the beginning, Chie demand Yosuke ten steaks while only demand Yu beef bowl. This indicates she expected more from Yosuke that she does from Yu. The second one is the fact that Chie seems to be the one who most upset when Yosuke "looked" at another girls. The third one is from P4 Arena game when the midnight channel appear, Yosuke is the first one she called to deny the nickname given to her, not Yukiko, not Yu, but Yosuke, and she did it unconsciously. and many more.

Since Yosuke is the goof the series and he seems to never get his way in it, I'll try to cut him some slack while not going too far off from the original canon of the game.

But then again, I guess I only see what I want to see, and believe what I want to believe. So, I hope those you share my believe and those who don't can equally enjoy what I write.