Sakura and Nako who are Yankees in Shekarashika Commercial School have been thrown to IZ University by their own parents. As much as their love of being yankees as well as their stage Name as Sakura and Namaiki(Nako), they have to learn how to be a normal student as well as learn to be a normal person, without having a fight with anyone.

The case of the baby potion have been spread around Korea and Japan. It makes the people shock and give confusion to everyone. As soon as Professor Furi work in an antidote. Another group became a victim once again.  This time... Its not only 3 members who was victimized, its 4. The problem is, Professor Han have a new partner in crime and the worst thing is... He and that person planned something worser than what he did to Tzuyu.  What if... The 01's line members of IZ*ONE Ha